1Denver, CO
No. 1 — Denver, CO. On the lists of 3 of 3 AIs; median place there: 6. AIs ranked it first because its 10th place for treatments hides West Nile cases that swing from 76 to over 600.



Did you know
The Brown Palace Hotel opened in 1892. Guests since then include the actor John Wayne, President Franklin D. Roosevelt and The Beatles.
- What it is
- Colorado's big city, 10th on Orkin's 2026 mosquito-treatment list.
- Its edge
- Climbed from 24th in 2019 to 10th, and Colorado's West Nile counts swing hugely.
- Who should know
- Useful for anyone who thinks a low pest ranking means low West Nile risk.
- Orkin treatment rank 202610th for treatments
- Founded1858
- HeadquartersDenver, Colorado
Why it is here
Denver ranked 10th on Orkin’s 2026 list, which counts new residential mosquito treatments from March 18, 2025, to March 18, 2026. [Orkin’s 2026 list](https://www.orkin.com/press-room/los-angeles-worst-mosquito-city-again)
Denver entered Orkin’s list at 24th in 2019; by 2024 it was 16th, and in 2026 it reached 10th. [Orkin’s 2019 list](https://www.orkin.com/press-room/orkins-2019-top-mosquito-cities) · [Orkin’s 2024 list](https://www.orkin.com/press-room/2024-top-mosquito-infested-cities) · [Orkin’s 2026 list](https://www.orkin.com/press-room/los-angeles-worst-mosquito-city-again)
Did you know
The U.S. Mint in Denver makes billions of coins each year, which makes it one of the busiest mints in the country. You can take a guided tour to see how coins are made.
History
In 1863, a small fire in a wooden building spread through downtown Denver in high winds, wrecking almost every building there. People rebuilt with brick, and a law required nearly every Denver building to use it—a change still visible in the city today.
Keep in mind
West Nile cases here can jump from year to year. In 2023, 619 people in Colorado were affected and 375 were hospitalized. Denver County had the most cases (95). Treatment counts do not show illness.






